Akums’ PRIBSYS Technology: Benefits of Preservative-Free Ophthalmic Formulations
Introduction
Eye drops are a frequent and successful dosage form to prevent and treat a variety of eye diseases such as glaucoma, dry eye, and allergies. However, many eye drop formulations contain preservatives, which can be harmful to the eye’s fragile tissues. This has led to the requirements of preservative-free eye drops. The use of preservatives in ophthalmic preparations to decrease microbial contamination is countered by the known ocular adverse effects of preservatives. It has a substantial impact on patients who require long-term therapy for chronic disorders such as glaucoma, dry eye, or inflammatory ocular surface diseases.
Akums’ PRIBSYS technology is an innovative solution that allows ophthalmic formulations to have an extended shelf life without the need for unwanted preservatives such as Benzalkonium chloride. PRIBSYS technology can help reduce the risk of ocular surface damage and inflammation, which can be particularly challenging for patients with pre-existing eye conditions such as dry eye syndrome or glaucoma.
The transition from Preserved to Preservative-Free:
Adherence to glaucoma drugs is a major issue in the treatment of glaucoma patients, with 24-59% failing to obtain the intended or complete impact of the treatment. A transition from a preserved to a preservative-free glaucoma ophthalmic formulation is associated with a considerable reduction in the frequency of ocular irritation signs and symptoms. This change also improves with corneal and conjunctival staining, erythema, conjunctival inflammation, and pseudolymphoma.
Maintain tear film stability
: Benzalkonium chloride (BAK) degrades the pre-corneal tear film’s stability. Any destabilization jeopardizes the tear film’s capacity to offer protection and trophic elements to the cornea. Pre-existing dry eye is understandably a prevalent problem related to the use of preservative-containing eye drop treatments.
No allergic reaction
Patients may develop ocular surface medicamentosa (OSM), a type of immune reaction affecting the eye and surrounding area, as a result of exposure to preservatives used in eye drops. This reaction can cause symptoms such as itching, redness, and swelling. Akums preservative-free Moxifloxacin Hydrochloride is used to treat eye infections such as bacterial conjunctivitis without producing an allergic reaction in the eye.
No ocular and corneal toxicity:
The acute toxicity of chemicals such as benzalkonium chloride (BAK), new detergents (such as Polyquad), and peroxide derivatives (such as Oxyd) are known to have cytotoxic side effects on the cornea and conjunctiva, leading to metaplasia and tear film breakdown. Akum’s Brimonidine in preservative-free formulations is utilized to decrease the pressure within the eye due to open-angle glaucoma and ocular hypertension without inducing any toxic impact on the cornea or ocular surface.
“Akum’s Drugs and Pharmaceuticals Ltd. becomes India’s first firm to receive DCGI nod for preservative-free Travoprost using PRIBSYS technology, eliminating the need for harsh preservatives like Benzalkonium chloride.”
Conclusion
Akums Drugs & Pharmaceuticals intends to continue developing preservative-free ophthalmic formulations with advantages in cost-effectiveness, durability, and patient adherence.