Ensuring Efficient Drug Delivery: Akums' Quality Evaluation of Nanoparticles
Introduction
The majority of the medications fall into Biopharmaceutics Classification System (BCS) class II, where low solubility is the rate-limiting step for penetration, nanoparticles are used to improve solubility. Analyzing physicochemical characteristics using suitable analytical techniques is crucial to ensure their efficiency, formulation process repeatability, functional performance, and system stability.
Nanoparticles improve drug delivery systems by enhancing solubility, bioavailability, and targeting. Analytical approaches aid in understanding their shape, size, and surface characteristics, allowing for tailored drug delivery to specific tissues or cells, and improving therapeutic efficiency while reducing adverse effects.
In the area of nanoparticle analysis, Akums employs advanced analytical techniques, including high-performance liquid chromatography (HPLC), Atomic Absorption Spectrometer, and scanning electron microscopy (SEM), which adhere to global standards. These methods are used to characterize and analyze the physicochemical properties of nanoparticle-based drugs, ensuring that they meet the highest standards of quality and effectiveness.
Why it is important to analyze the quality of nanoparticles?
It is important to analyze the chemical-physiological characteristics of nanoparticles because these characteristics can affect how the nanoparticles interact with biological systems and impact their efficacy and safety. Understanding the size, shape, surface charge, and other properties of drug nanoparticles can help to optimize their design and ensure that they can be administered safely and effectively.
The quality and analysis of nanosystems are much more challenging than those of bulk materials or microparticle systems. At the nanoscale, several physical parameters differ from their bulk counterparts. Nanoparticles are inherently unstable and tend to aggregate and when drug nanoparticles encounter bodily fluids, they tend to disintegrate quickly. In nanoparticle formulations, it is crucial to analyze desirable particle characteristics and their critical quality attributes (CQAs) to identify whether the particles should be engineered to dissolve instantly or whether the aim is controlled drug release from solid particles.
Technique for nanoparticles characterization
Understanding drug release is crucial in developing targeted delivery systems. High-performance liquid chromatography (HPLC) is commonly used to assess the stability and purity of nanoparticles. It quantifies degradation products and impurities and detects chemical changes during storage and use. It’s commonly used to analyze nanoparticle drug stability under varying conditions, as well as to measure their concentration over time. Moreover, it separates and quantifies components, ensuring nanoparticle purity and meeting regulatory standards. Overall, HPLC is a powerful technique in pharmaceuticals for developing and ensuring the quality of nanoparticles.
Akums possesses a considerable collection of more than 400 HPLC machines that are solely dedicated to the analysis of their drug formulations. These HPLC machines are high-tech instruments utilized for performing precise and accurate analyses of drugs to verify their quality, potency, and purity.
Electron microscopy techniques like SEM are crucial for managing the physical and chemical characteristics of nanoparticles. They provide information on particle size, structure, and morphology, and aid in developing effective drug delivery systems. SEM’s unique imaging and detection capabilities allow for the analysis of structural morphology at the atomic or molecular level.
Nanoparticle characterization involves various analytical techniques, such as IR and Raman spectroscopy, light scattering-based techniques, and zeta potential. IR and Raman’s spectroscopy reveal the chemical composition and functional groups and crystalline structure.
Akums recognizes the enormous potential of nanoparticles in targeted delivery to specific tissues or cells. However, to harness these benefits, it’s crucial to have a deep understanding of the morphology, size, and surface properties of nanoparticles. This information is essential for the development of effective and efficient drug delivery systems. Our scientists at research labs continuously endeavor to research on nano-technology to improve the quality of medicines.