The Tablet-in-Tablet Formulation Approach has the Potential to Addressing Controlled Drug Release Delivery Complexities

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The tablet continues to be the most widely used oral dosage form. The reasons for its popularity among the masses are patient acceptability and stability. The coating of any tablet forms an important part of a tablet as it is responsible for taste masking, color, mouthfeel, and texture. A tablet-in-tablet formulation is gaining traction these days as it is advantageous over the conventional tablet formulation. Let us understand the tablet-in-tablet formulation and how it addresses controlled drug release delivery complexities.


What is a tablet in tablet formulation?


As the name suggests, tablet in tablet formulation means a tablet encapsulated within another tablet. It has a core tablet (inside) and an outer tablet (outside). The chemical makeup of the two tablets used can be completely different from each other. One may wonder why there is a requirement for such a tablet in the first place. Well, there are reasons ranging from compatibility to drug release to convenience of consumption and others that call for the need to have a tablet in tablet formulation.



Why is a tablet-in-tablet formulation needed?


This formulation has a plethora of advantages. Some of them are:


  • Certain drugs can not be combined together due to their incompatibility. However, a tablet-in-tablet formulation gives scope for such drugs due to the compartmentalization it provides.
  • Creating modified-release products, such as delayed releases, becomes easy with this formulation. Reaching the target site is effectively achieved as different medications have different drug release profiles.
  • This is a great relief for people who are on combination therapy since one tablet carries the function of two tablets.
  • Dose flexibility is another great advantage of this formulation. The size and composition of the tablet can be altered to achieve the desired strength based on patients’ requirements.
  • This formulation enhances the stability of the active ingredient especially those that are hygroscopic or thermo-labile. Such actives are usually chosen for making the inner core.



Role of Akums Drugs & Pharmaceuticals Ltd


India’s largest third-party contract pharmaceutical giant Akums Drugs & Pharmaceuticals Ltd is always a step ahead when it comes to embracing innovative methods to address the changing needs of its partner brands and in turn the customers. Akums uses the latest technology to address the issue of increased tablet size when enhancing the strength of the drug in a tablet in tablet formulation. The tablet size is always a cause of concern as it dictates patient compliance to a large extent. In addition, Akums ensures that the final product always undergoes a series of tests to be at par with the intended quality and strength as indicated, for instance, disintegration, hardness, thickness, and weight variation tests. Having a massive manufacturing capacity that can generate 140 million tablets in a day, Akums has well-equipped fifteen state-of-the-art facilities in the regions of Haridwar, Kotdwar, and Baddi. The company has a specialized workforce that receives regular training on the latest developments in the pharmaceutical industry and how to make use of technological advancements to supply the best-in-class products to its wide clientele.