Akums’ PRIBSYS Technology


Akums’ PRIBSYS Technology: Benefits of Preservative-Free Ophthalmic Formulations


Eye drops are a frequent and successful technique to treat a variety of eye diseases such as glaucoma, dry eye, and allergies. However, many traditional eye drop formulations contain preservatives, which can be harmful to the eye's fragile tissues. This has increased demand for preservative-free eye drops.

Akums’ PRIBSYS technology is an innovative solution that allows ophthalmic formulations to have an extended shelf life without the need for harsh preservatives such as Benzalkonium chloride. By eliminating the use of harsh preservatives, PRIBSYS technology can help reduce the risk of ocular surface damage and inflammation, which can be particularly problematic for patients with pre-existing eye conditions such as dry eye syndrome or glaucoma.

Preservative-free over Preservative Ophthalmic Formulation

The use of preservatives in ophthalmic preparations to decrease microbial contamination is countered by the known ocular adverse effects of preservatives. It has a substantial impact on patients who require long-term therapy for chronic disorders such as glaucoma, dry eye, or inflammatory ocular surface diseases. Akum's PRIBSYS technology extends the shelf life of ophthalmic formulations without the use of harsh preservatives like Benzalkonium chloride.

Maintain tear film stability: Benzalkonium chloride (BAK) degrades the precorneal tear film's stability. Any destabilization jeopardizes the tear film's capacity to offer protection and trophic elements to the cornea. Pre-existing dry eye is understandably a prevalent problem related to the use of preservative-containing eye drop treatments.

No allergic reaction: People may develop ocular surface medicamentosa (OSM), a type of immune reaction affecting the eye and surrounding area, as a result of exposure to preservatives used in eye drops. This reaction can cause symptoms such as itching, redness, and swelling. Akums preservative-free Moxifloxacin Hydrochloride is used to treat eye infections such as bacterial conjunctivitis without producing an allergic reaction in the eye.

No ocular and corneal toxicity: The acute toxicity of chemicals such as benzalkonium chloride (BAK), new detergents (such as Polyquad), and peroxide derivatives (such as Oxyd) are known to have cytotoxic side effects on the cornea and conjunctiva, leading to metaplasia and tear film breakdown. Akum’s Brimonidine in preservative-free formulations is utilized to decrease the pressure within the eye due to open-angle glaucoma and ocular hypertension without inducing any toxic impact on the cornea or ocular surface.

The transition from Preserved to Preservative-Free: Adherence to glaucoma drugs is a major issue in the treatment of glaucoma patients, with 24-59% failing to obtain the intended or complete impact of the treatment. A transition from a preserved to a preservative-free glaucoma ophthalmic formulation is associated with a considerable reduction in the frequency of ocular irritation signs and symptoms. This change also improves with corneal and conjunctival staining, erythema, conjunctival inflammation, and pseudolymphoma.

"Akum's Drugs and Pharmaceuticals Ltd. becomes India's first firm to receive DCGI nod for preservative-free Travoprost using PRIBSYS technology, eliminating the need for harsh preservatives like Benzalkonium chloride."


The goal to provide a safer and more effective option for eye care is driving the trend toward preservative-free eye drops. Preservative-free eye drops can help to limit potential harmful effects on the eye and create a more comfortable experience for the patient by avoiding the use of preservatives.

Akums Drugs & Pharmaceuticals intends to continue developing preservative-free ophthalmic formulations with advantages in cost-effectiveness, durability, and patient adherence.